Study identifies critical link between inflammation and liver regeneration
Mayo Clinic researchers and collaborators have discovered a critical role that inflammation plays in liver regeneration after liver resection. While effective liver regeneration requires a certain amount of inflammation, too much of it causes liver regeneration failure. The researchers found that patients with dysfunctional liver regeneration after resection have an overwhelming, aggravated inflammatory response in the liver.
Researchers also discovered that patients experiencing dysfunctional liver regeneration had a significantly dysregulated gene known as DUSP4, which is found within liver sinusoidal endothelial cells (LSECs). This finding could help support targeted therapeutic strategies administered before or after surgical resection to prevent patients from experiencing liver failure.